›› 2019, Vol. 46 ›› Issue (5): 1316-1322.doi: 10.16431/j.cnki.1671-7236.2019.05.008

• Physiology and Biochemistry • Previous Articles     Next Articles

Protective Effect of Camel Urine on Liver Injury Induced by CCl4 in Mice

HAO Sina1, ZHUO Na1, HAI Le1, YI Li1, MING Liang1, JIRIMUTU1,2,3   

  1. 1. Key Laboratory of Dairy Biotechnology and Bioengineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot 010018, China;
    2. Inner Mongolia Camel Conservation Society, Hohhot 010018, China;
    3. Inner Mongolia Institute of Camel Research, Badanjiran 737300, China
  • Received:2018-09-18 Online:2019-05-20 Published:2019-05-20

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Abstract:

In this study,protective effect of camel urine on liver injury induced by CCl4 in mice was investigated.Forty mice were randomly divided into five groups:Normal group,model group,low-dose camel urine group (170 mg/kg),medium dose camel urine group (340 mg/kg) and high dose camel urine group (500 mg/kg),respectively.The normal group and model group received the same amount of saline infusions once a day,while 3 camel urine groups received different amount of camel urine.All mice were given continuous administration for 14 d and injected with 20% CCl4 and olive oil solution to establish an acute liver injury model except the control group at the end of the experiment.Mice have sacrificed after 12 h post-CCl4 injection when blood and livers were collected,and the liver weight and the liver index were recorded and calculated.Then the related serum indicators and the pathological examination of liver tissue were detected.The results showed that compared with the model group,the level of serum ALT,AST,TBIL,ALP,GLU,TP in low,middle,high dose camel urine groups were decreased,while the serum ALB level was increased with high dose group had a better effect.According to the results of the pathological section,the liver histopathological damage of mice in 3 camel urine groups were all alleviate,and that in the high dose camel urine group was very similar to the normal group.In addition,it could be seen from the results that among the three of camel urine groups,the higher concentration had a better therapeutic effect,indicating that the effect of camel urine was dose-dependent.In summary,camel urine had a certain preventive effect on CCl4-induced liver injury in mice,and the high dose was the better.

Key words: camel urine; carbon tetrachloride (CCl4); liver injury; prevention

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