›› 2011, Vol. 38 ›› Issue (5): 74-77.

• 生物技术 • Previous Articles     Next Articles

Application of RNAi in Trangenic Mice

CHEN Zhi-bao1, WANG Dong-xu2, WAN Jia-yu2, PAN Peng-peng2, LI Sha2, GAO Hong-wei2   

  1. 1. School of Life Sciences,Heilongjiang Bayi Agricultural University,Daqing 163319,China;2. The Military Veterinary Institute,Academy of Military Medical Sciences of PLA,Changchun 130062,China
  • Received:2010-12-28 Revised:1900-01-01 Online:2011-05-20 Published:2011-05-20

Abstract: RNA interference degrades mRNA specifically and potently though the mediation of corresponding double-stranded RNA and leads to post-transcriptional gene silencing. Recently,small interfering RNA duplexes(siRNA) is used in mammalian cells to silence gene expression. At the same time,RNAi is a powerful tool for studying gene function in vivo. This review provides an overview of transgenic RNA interference in mice.

Key words: RNA interference; double-stranded RNA; transgenic mice

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