丁酸钠对犊牛胃肠道发育的研究进展

doi:10.16431/j.cnki.1671-7236.2019.08.020

摘要/Abstract

摘要：

丁酸钠是一种绿色新型饲料添加剂，目前在动物饲料中应用广泛，且效果良好。作者主要介绍了丁酸钠的生物学功能、对犊牛胃肠道发育的影响及其在犊牛日粮中的应用效果。重点总结了丁酸钠促进犊牛胃肠道发育的影响机制，包括作为胃肠道组织的能量来源调控激素和生长因子的分泌，提高消化和吸收相关酶的分泌及活性，提高肠道免疫细胞保护性蛋白的分泌等。现有研究表明，日粮干物质中添加0.3%丁酸钠就能达到促进犊牛生长和胃肠道发育的效果，但具体添加水平、添加阶段和方式等尚不明确。此外，日粮粗饲料水平、精料发酵所产生的内源丁酸对外源丁酸钠的作用效果是否有影响也鲜有报道，有待进一步开展研究。

关键词: 丁酸钠; 犊牛; 胃肠道发育

Abstract:

Sodium butyrate is a new feed additive which is widely used in animal feed, and its effects is reported to be positive in many literatures.This paper mainly introduces the biological function of sodium butyrate, its effect on development of calves' gastrointestinal tract and the effects of being used as calves' feed additive.The authors mainly reviewed the mechanism of sodium butyrate promoting the development of gastrointestinal tract, including being used as energy source of gastrointestinal tract of animal, regulating secretion of hormones and growth factor, improving secretion and activity of digesting and absorption related enzymes, and increasing secretion of protective proteins of intestinal immune cells, etc.The present studies showed that addition of 0.3% sodium butyrate into feed dry matter could promote the development of gastrointestinal tract and growth of calves, but the addition level, phase and way were need to be further researched.Besides, there is few report on the influences of dietary forage level and endogenous butyrate which produced by concentrate fermentation on function of exogenous butyrate, which need to be further researched.

Key words: sodium butyrate; calves; gastrointestinal tract development

中图分类号:

S816.7

俞文靓, 王超, 王敏, 赵圣国, 林波. 丁酸钠对犊牛胃肠道发育的研究进展[J]. 《中国畜牧兽医》, 2019, 46(8): 2354-2359.

YU Wenjing, WANG Chao, WANG Min, ZHAO Shengguo, LIN Bo. Research Progress on the Effect of Sodium Butyrate on the Development of Gastrointestinal Tract of Calves[J]. , 2019, 46(8): 2354-2359.

参考文献 44

[1]	郜飞燕,邹君彪.丁酸钠的生理功能及其在养殖业中的应用研究进展[J].国外畜牧学(猪与禽),2017,37(6):94-96. GAO F Y,ZOU J B.Progress in physiological function of sodium butyrate and its application in aquaculture[J]. Foreign Animal Husbandry (Pig and Poultry),2017,37(6):94-96.(in Chinese)
[2]	MALLO J J,BALFAGÓN A,GRACIA M I,et al.Evaluation of different protections of butyric acid aiming for release in the last part of the gastrointestinal tract of piglets[J]. Journal of Animal Science,2012,90(suppl 4):227-229.
[3]	GUILLOTEAU P,ZABIELSKI R,DAVID J C,et al.Sodium-butyrate as a growth promoter in milk replacer formula for young calves[J]. Journal of Dairy Science,2009,92(3):1038-1049.
[4]	陈业,赵怀宝.丁酸钠在动物肠道功能方面的生物学意义[J].饲料研究,2018,2:30-33. CHEN Y,ZHAO H B.Biological significance of sodium butyrate in animal intestinal function[J]. Feed Research,2018,2:30-33.(in Chinese)
[5]	GUILLOTEAU P,ZABIELSKI R,BLUM J W.Gastrointestinal tract and digestion in the young ruminant:Ontogenesis,adaptations,consequences and manipulations[J]. Journal of Physiology and Pharmacology,2009,60(suppl 3):37-46.
[6]	FLAGA J,GÓRKA P,KOWALSKI Z M,et al.Insulin-like growth factors 1 and 2(IGF-1 and IGF-2) mRNA levels in relation to the gastrointestinal tract (GIT) development in newborn calves[J]. Polish Journal of Veterinary Sciences,2011,14(4):605-613.
[7]	HEINRICHS A J,LESMEISTER K E,GARNSWORTHY P C.Rumen development in the dairy calf[A].Calf & Heifer Rearing:Principles of Rearing the Modern Dairy Heifer from Calf to Calving[C].2005.
[8]	HILL T M,ND B H,ALDRICH J M,et al.Effect of milk replacer program on digestion of nutrients in dairy calves[J]. Journal of Dairy Science,2010,93(3):1105-1115.
[9]	KHAN M A,BACH A,WEARY D M,et al.Invited review:Transitioning from milk to solid feed in dairy heifers[J]. Journal of Dairy Science,2016,99(2):885-902.
[10]	GÓRKA P,KOWALSKI Z M,PIETRZAK P,et al.Is rumen development in newborn calves affected by different liquid feeds and small intestine development?[J]. Journal of Dairy Science,2011,94(6):3002-3013.
[11]	李娟,吴永胜,雷春龙,等.丁酸盐在畜禽生产中的应用研究进展[J].现代农业科技,2017,5:234-235. LI J,WU Y S,LEI C L,et al.Progress in the application of butyrate in livestock and poultry production[J]. Modern Agricultural Science and Technology,2017,5:234-235.(in Chinese)
[12]	BEDFORD A,GONG J.Implications of butyrate and its derivatives for gut health and animal production[J]. Animal Nutrition,2018,4(2):151-159.
[13]	陈小兵,许毅,陶正国.丁酸钠的研究进展[J].饲料与畜牧:新饲料,2007,3:33-34. CHEN X B,XU Y,TAO Z G.Research progress of sodium butyrate[J]. Feed and Livestock:New Feed,2007,3:33-34.(in Chinese)
[14]	PENNER G B,ASCHENBACH J R,GABEL G,et al.Epithelial capacity for apical uptake of short chain fatty acids is a key determinant for intraruminal pH and the susceptibility to subacuteruminal acidosis in sheep[J]. Journal of Nutrition,2009,139(9):1714-1720.
[15]	王曼曼,陈宝江,梁陈冲,等.丁酸钠作用机理及其在畜牧生产中应用研究进展[J].当代畜禽养殖业,2011,7:30-32. WANG M M,CHEN B J,LIANG C C,et al.Progress in the mechanism of sodium butyrate and its application in livestock production[J]. Contemporary Livestock and Poultry Breeding,2011,7:30-32.(in Chinese)
[16]	余荣,徐小芳,王雯熙.丁酸对动物肠道影响的研究进展[J].中国畜牧杂志,2012,48(16):64-68. YU R,XU X F,WANG W X.Research progress of butyric acid on animal intestines[J]. Chinese Journal of Animal Science,2012,48(16):64-68.(in Chinese)
[17]	MENTSCHEL J,LEISER R,MVLLING C,et al.Butyric acid stimulates rumen mucosa development in the calf mainly by a reduction of apoptosis[J]. Archiv für Tierernaehrung,2001,55(2):85-102.
[18]	赵会利,高艳霞,李建国,等.丁酸钠对断奶犊牛生长、血液生化指标及胃肠道发育的影响[J].畜牧兽医学报,2013,44(10):1600-1608. ZHAO H L,GAO Y X,LI J G,et al.Effect of sodium butyrate on growth,serum biochemical parameters and gastrointestinal development of weaning calves[J]. Acta Veterinaria et Zootechnica Sinica,2013,44(10):1600-1608.(in Chinese)
[19]	邴新帅.丁酸钠与沙蒿多糖对断奶羔羊肠道发育及胰高血糖素样肽-2的影响[D].呼和浩特:内蒙古农业大学,2018. BING X S.Effects of sodium butyrate and Artemisia sphaeroides polysaccharides on intestinal development and glucagon-like peptide-2 in weaned lambs[D].Huhhot:Inner Mongolia Agricultural University,2018.(in Chinese)
[20]	郭传珍,曹兵海.丁酸钠对肉鸡肠道pH值、微生物菌群和挥发性脂肪酸的影响研究[J].中国家禽,2009,31(21):14-17. GUO C Z,CAO B H.Effects of sodium butyrate on intestinal pH,microbial flora and volatile fatty acids in broilers[J]. China Poultry,2009,31(21):14-17.(in Chinese)
[21]	GUILLOTEAU P,MARTIN L,EECKHAUT V,et al.From the gut to the peripheral tissues:The multiple effects of butyrate[J]. Nutrition Research Reviews,2010,23(2):366-384.
[22]	GÁLFI P,BOKORI J.Feeding trial in pigs with a diet containing sodium n-butyrate[J]. Acta Veterinaria Hungarica,1990,38(1-2):3-17.
[23]	芦娜,王恬,钟翔.不同的丁酸产品在猪禽生产中的应用研究进展[J].动物营养学报,2015,27(2):359-368. LU N,WANG T,ZHONG X.Advances in the application of different butyric acid products in pig and poultry production[J]. Chinese Journal of Animal Nutrition,2015,27(2):359-368.(in Chinese)
[24]	王继凤.丁酸钠对断奶仔猪肠黏膜结构及黏膜免疫相关细胞影响的研究[D].北京:中国农业大学,2005. WANG J F.Effects of sodium butyrate on intestinal mucosal structure and mucosal immune-related cells in weaned piglets[D].Beijing:China Agricultural University,2005.(in Chinese)
[25]	熊海涛.丁酸钠对仔猪抗大肠杆菌感染的作用及其机制研究[D].杭州:浙江大学,2016. XIONG H T.Effect of sodium butyrate on piglets against Escherichia coli infection and its mechanism[D].Hangzhou:Zhejiang University,2016.(in Chinese)
[26]	刘欣欣.高精料日粮对反刍动物肝脏细胞凋亡的影响及丁酸钠调控作用[D].南京:南京农业大学,2016. LIU X X.Effect of high concentrate diet on hepatocyte apoptosis in ruminants and regulation of sodium butyrate[D].Nanjing:Nanjing Agricultural University,2016.(in Chinese)
[27]	姚蕾,孙伊乔,李艾黎,等.丁酸钠对β-乳球蛋白过敏小鼠淋巴细胞的体外影响[J].中国食品学报,2017,12:35-41. YAO L,SUN Y Q,LI A L,et al.Effects of sodium butyrate on lymphocytes of β-lactoglobulin allergic mice in vitro[J]. Chinese Journal of Food Science,2017,12:35-41.(in Chinese)
[28]	王晶晶.丁酸钠对LPS诱发的乳腺炎小鼠血乳屏障的保护作用及其机制的初步研究[D].长春:吉林大学,2018. WANG J J.Protective effect of sodium butyrate on the blood-milk barrier of LPS-induced mastitis mice and its mechanism[D].Changchun:Jilin University,2018.(in Chinse)
[29]	SAUER J,RICHTER K K,POOL-ZOBEL B L.Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells[J]. Journal of Nutritional Biochemistry,2007,18(11):736-745.
[30]	SAKATA T,TAMATE H.Rumen epithelial cell proliferation accelerated by rapid increase in intraruminal butyrate[J]. Journal of Dairy Science,1978,61(8):1109-1113.
[31]	SANDER E G,WARNER R G,HARRISON H N,et al.The stimulatory effect of sodium butyrate and sodium propionate on the development of rumen mucosa in the young calf[J]. Journal of Dairy Science,1959,42(9):1600-1605.
[32]	GÓRKA P,PIETRZAK P,KOTUNIA A,et al.Effect of method of delivery of sodium butyrate on maturation of the small intestine in newborn calves[J]. Journal of Dairy Science,2014,97(2):1026-1035.
[33]	KATO S I,SATO K,CHIDA H,et al.Effects of Na-butyrate supplementation in milk formula on plasma concentrations of GH and insulin,and on rumen papilla development in calves[J]. Journal of Endocrinology,2011,211(3):241-248.
[34]	GÓRKA P,KOWALSKI Z M,PIETRZAK P,et al.Effect of method of delivery of sodium butyrate on rumen development in newborn calves[J]. Journal of Dairy Science,2011,94(11):5578-5588.
[35]	BLÄTTLER U,HAMMON H M,MOREL C,et al.Feeding colostrum,its composition and feeding duration variably modify proliferation and morphology of the intestine and digestive enzyme activities of neonatal calves[J]. The Journal of Nutrition,2001,131(4):1256-1263.
[36]	VI R L B,MCLEOD K R,KLOTZ J L,et al.Rumen development,intestinal growth and hepatic metabolism in the pre-and postweaning ruminant[J]. Journal of Dairy Science,2004,87:E55-E65.
[37]	GREENWOOD R H,MORRILL J L,TITGEMEYER E C.Using dry feed intake as a percentage of initial body weight as a weaning criterion1[J]. Journal of Dairy Science,1997,80(10):2542-2546.
[38]	MOQUET P C A,ONRUST L,VAN IMMERSEEL F,et al.Importance of release location on the mode of action of butyrate derivatives in the avian gastrointestinal tract[J]. World's Poultry Science Journal,2016,72(1):61-80.
[39]	KOWALSKI Z M,GÓRKA P,FLAGA J,et al.Effect of microencapsulated sodium butyrate in the close-up diet on performance of dairy cows in the early lactation period[J]. Journal of Dairy Science,2015,98(5):3284-3291.
[40]	GÓRKA P,KOWALSKI Z M,ZABIELSKI R,et al.Invited review:Use of butyrate to promote gastrointestinal tract development in calves[J]. Journal of Dairy Science,2018,101(6):4785-4800.
[41]	CAVINI S,IRAIRA S,SIURANA A,et al.Effect of sodium butyrate administered in the concentrate on rumen development and productive performance of lambs in intensive production system during the suckling and the fattening periods[J]. Small Ruminant Research,2015,123(2-3):212-217.
[42]	SLUSARCZYK K,STRZETELSKI J A,FURGA-DIERZUK I.The effect of sodium butyrate on calf growth and serum level of beta-hydroxybutyric acid[J]. Journal of Animal & Feed Sciences,2010,19(3):348-357.
[43]	WANAT P,GÓRKA P,KOWALSKI Z M.Short communication:Effect of inclusion rate of microencapsulated sodium butyrate in starter mixture for dairy calves[J]. Journal of Dairy Science,2015,98(4):2682-2686.
[44]	BULL L S,BUSH L J,FRIEND J D,et al.Incidence of ruminal parakeratosis in calves fed different rations and its relation to volatile fatty acid absorption[J]. Journal of Dairy Science,1965,48(11):1459-1466.