高原哺乳动物低氧感受器的研究进展

中国畜牧兽医

高原哺乳动物低氧感受器的研究进展

胡明军^1,2, 邓霄禹^1,2, 江明锋^1,2

1. 动物遗传育种学国家民委-教育部重点实验室,四川成都 610041;
2. 西南民族大学生命科学与技术学院,四川成都 610041

收稿日期:2012-02-09 出版日期:2012-09-20 发布日期:2012-09-18
通讯作者: 江明锋(1971－),男,四川人,教授,博士,主要研究高原生物基因组学及优质基因的利用。E-mail:mingfengjiang@vip.sina.com E-mail:mingfengjiang@vip.sina.com
作者简介:胡明军(1986－),男,河南人,硕士生,研究方向:高原动物低氧适应机制。
基金资助:
教育部科学技术研究重点项目(210264);中央高校基本科研业务费专项资金(10NZYZJ01),受2011年国家外专项目资助。

Research Progress on Hypoxia Receptor in Plateau Mammals

HU Ming-jun^1,2, DENG Xiao-yu^1,2, JIANG Ming-feng^1,2

1. Key Laboratory of Animal Genetics & Breeding, State Ethnic Affairs Commission and Ministry of Education, Chengdu 610041,China;
2. College of Life Science and Technology,Southwest University for Nationalities,Chengdu 610041,China

Received:2012-02-09 Online:2012-09-20 Published:2012-09-18

摘要/Abstract

摘要： 目前,已发现了许多与氧感受器相关的基因,如血红素蛋白、NADPH氧化还原酶、线粒体电子传递链成分、天冬酰胺羟化酶及HIF1等。虽然低氧研究在哺乳动物的器官水平及分子水平取得了很大的进展,但是低氧信号传导机制并不是很清楚。作者综述了高原地区哺乳动物低氧感受器方面的进展,通过对高原地区哺乳动物机体对低氧适应的机制进行总结,帮助人们了解哺乳动物对高原低氧环境的适应机制。

关键词: 低氧诱导因子; 氧感受器; 高原哺乳动物

Abstract: Many receptor genes related to hypoxia were found in plateau mammals. The main hypoxia receptor genes were hemoglobin,NADPH oxidoreductase,mitochondrial electron transport chain components, asparagine hydroxylase,HIF1 and so on. Although, a great progress at organ level and molecular level about mammals was made in recent years, the hypoxia signal pathway is not very clear. The recent progress of hypoxia receptor genes in plateau mammals was reviewed in this paper. The profiling of hypoxia receptors in plateau mammals will help us to understand how mammals adopt to the hypoxia environment in highland.

Key words: hypoxia receptors; oxygen sensors; plateau mammal 

中图分类号:

S811.2

胡明军, 邓霄禹, 江明锋. 高原哺乳动物低氧感受器的研究进展[J]. 中国畜牧兽医.

HU Ming-jun, DENG Xiao-yu, JIANG Ming-feng. Research Progress on Hypoxia Receptor in Plateau Mammals[J]. .

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