白藜芦醇对Nrf2、NF-κB和Wnt信号通路的调控及其在动物生产中的应用

doi:10.16431/j.cnki.1671-7236.2023.02.009

摘要/Abstract

摘要： 白藜芦醇(resveratrol,RES)是一种天然的非黄酮类多酚化合物,广泛存在于多种植物组织中,如葡萄、虎杖和花生等,是植物抵御病原微生物入侵和维持自身稳态的重要物质,因此也被称作植物抗毒素。RES具有良好的抗氧化、抗炎和抗菌特性,在改善动物抗逆性、提高免疫能力和维持肠道健康等方面发挥重要作用。RES通过调控核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf2)-Kelch样环氧氯丙烷相关蛋白-1(Kelch-like epichlorohydrin-related protein-1,keap1)促进畜禽体内Nrf2因子的表达,提高抗氧化因子表达和抗氧化酶活性,缓解氧化应激;通过核因子-κB (nuclear factor kappa-B,NF-κB)信号通路降低机体炎性因子表达水平,减少炎症反应。在动物肠道健康方面,RES可通过调控Wnt/β-连环蛋白(Wnt/β-catenin)信号通路促进肠道上皮细胞增殖分化,改善肠道黏膜屏障完整性,促进肠道微生物定植,进而改善肠道菌群结构。在动物生产中,RES作为饲料添加剂可提高动物的生长性能,释放生长潜力,并改善畜禽产品品质。同时,RES可增强动物的免疫功能,提高其抵御病原体的能力,降低疾病的发生率。目前,RES在畜禽生产中得到广泛的研究与应用,但对其具体作用机制仍需进一步了解。作者介绍了RES调控Nrf2-Keap1、NF-κB和Wnt/β-catenin信号通路的机制,并展望了其在畜禽生产中的应用前景,以期为RES在畜禽生产中的深度应用提供理论依据。

关键词: 白藜芦醇; Nrf2-Keap1; NF-κB; Wnt/β-catenin; 畜禽生产

Abstract: Resveratrol (RES) is a natural non-flavonoid polyphenol compound that exists widely in various plant tissues,such as grapes,tab wraps,and peanuts,it is an important substance that plants resist the invasion of pathogenic microorganisms and maintain their stability,so it is also called plant antitoxin.RES has good antioxidant,anti-inflammatory,and antibacterial characteristics,and plays an important role in improving animal resistance,improving immune capacity,and maintaining intestinal health.RES can promote the expression of nuclear factor E2-related factor 2 (Nrf2) in livestock and poultry by regulating Nrf2-Kelch-like oxide propylene-1 (keap 1),and improve antioxidant factor expression and antioxidizes activity,relieves oxidation stress,reduces the level of inflammatory factor expression and the inflammatory response by regulating nuclear factor-κB (NF-κB) signaling pathway.In terms of animal intestinal health,RES can promote the proliferation and differentiation of intestinal epithelial cells by regulating the Wnt/β-serial protein (Wnt/β-catenin) signaling pathway,improving intestinal mucosal barrier integrity,promoting intestinal microbial planting,and then improving the intestinal flora structure.As a natural supplementation,RES can improve the growth performance and growth potential of animals,and improve the quality of livestock and poultry products.At the same time,RES can enhance the immune function of animals,improve their ability to resist pathogens,and reduce the incidence of disease.At present,RES has been widely used in the production of livestock and poultry,but it still needs to be further understood by its specific mechanism.The authors introduced the specific mechanism of RES regulating Nrf2-Keap1,NF-κB and Wnt/β-catenin signaling pathways,and its application prospects in livestock and poultry production,in order to provide a theoretical basis for the in-depth application of RES in animal production.

Key words: resveratrol; Nrf2-Keap1; NF-κB; Wnt/β-catenin; livestock and poultry production

中图分类号:

S816.7

高阳, 杜鑫, 马雪, 张影梅, 霍长青. 白藜芦醇对Nrf2、NF-κB和Wnt信号通路的调控及其在动物生产中的应用[J]. 中国畜牧兽医, 2023, 50(2): 512-518.

GAO Yang, DU Xin, MA Xue, ZHANG Yingmei, HUO Changqing. Regulation of Resveratrol on Nrf2,NF-κB and Wnt Signaling Pathways and Its Application in Animals Production[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 512-518.

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