中国畜牧兽医 ›› 2019, Vol. 46 ›› Issue (10): 2973-2980.doi: 10.16431/j.cnki.1671-7236.2019.10.018

• 动物营养与饲料科学 • 上一篇    下一篇

精氨酸与高精氨酸的联系及其代谢产物一氧化氮对妊娠母猪繁殖性能的作用

张奇1, 卢健2, 姜海龙1, 车东升1, 杨海天1   

  1. 1. 吉林农业大学动物科学技术学院, 长春动物生产及产品质量安全教育部重点实验室, 长春 130118;
    2. 临江市动物疫病预防控制中心, 临江 134600
  • 收稿日期:2019-03-28 出版日期:2019-10-20 发布日期:2019-10-21
  • 通讯作者: 姜海龙 E-mail:hljiang@jau.edu.cn
  • 作者简介:张奇(1993-),男,河南信阳人,硕士,研究方向:单胃动物营养与饲料科学,E-mail:1085621605@qq.com
  • 基金资助:
    国家重点研发计划项目(2017YFD0502001);母猪精准功能性氨基酸模型的优化与示范(20170309003NY)

The Relationship Between Arginine and High Arginine and Its Metabolite Nitric Oxide on the Reproductive Performance of Pregnant Sows

ZHANG Qi1, LU Jian2, JIANG Hailong1, CHE Dongsheng1, YANG Haitian1   

  1. 1. Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China;
    2. Linjiang City Animal Disease Prevention and Control Center, Linjiang 134600, China
  • Received:2019-03-28 Online:2019-10-20 Published:2019-10-21

摘要: 一氧化氮(NO)既是妊娠期母体和胎儿体内平衡的关键调节因子,也是促进母体心血管变化、胎儿发育和生长以及适应宫内外生活的重要物质。精氨酸(Arg)与高精氨酸(h-Arg)是一对同源氨基酸,h-Arg是非必需的阳离子氨基酸,其可能由赖氨酸分解代谢或其前体Arg的氨基转移合成。它们均为NO的前体物质,对孕体具有相似的功能。在母猪妊娠期补饲Arg或h-Arg,能够增加孕体NO的含量。NO通过调控激素、血管的生成与增加养分供给等增加胚胎附植、减少胚胎死亡、增强胎儿发育,进而改善胎儿宫内发育受限(IUGR)与母猪繁殖性能。随着妊娠的进行,孕体氧化代谢增加,会产生大量的自由基。Arg或h-Arg代谢产生的NO通过上调Nrf2通路刺激谷胱甘肽(GSH)代谢相关基因的表达,增强孕体抗氧化能力,保证孕体与胎儿的健康发育。作者针对母猪妊娠期补充Arg或h-Arg,通过其代谢产物NO改善母猪IUGR、提高繁殖性能、增强机体抗氧化能力的作用与可能存在的机制进行综述,旨在为Arg与h-Arg在妊娠母猪上的应用提供理论支持。

关键词: 精氨酸; 高精氨酸; NO; 妊娠母猪

Abstract: Nitric oxide (NO) is a key regulator of maternal and fetal homeostasis during pregnancy.Moreover,NO is also an important substance in promotes maternal cardiovascular changes,fetal development and growth,and adaptation to intrauterine and extrauterine life.Arginine (Arg) and homoarginine (h-Arg) are a pair of homologous amino acids.h-Arg is a non-essential cationic amino acid which can be synthesized by lysine catabolism or amino transfer of its precursor Arg.They have similar functions in the physiological and biochemical aspects during pregnancy,because they are both metabolic products of NO.Supplementation of Arg or h-Arg during the gestation period can increase the content of NO in pregnant sow.NO can increases the attachment of embryos,reduces embryonic death and enhances fetal development by regulating the production of hormones,angiogenesis and increasing the supply of nutrients,and then improving the intrauterine growth restriction (IUGR) and reproductive performance of sow.As the pregnancy progresses,body oxidative metabolism has been increased,and a large amount of free radicals are produced.NO produced by Arg or h-Arg metabolism up-regulates the Nrf2 pathway and stimulates the expression of genes involved in glutathione (GSH) metabolism,enhances the antioxidant capacity of the sow,and ensures the healthy development of the gestational body and the fetus.In this paper,the authors focus on the supplement of Arg or h-Arg during the gestation period of sows,and discuss the functions of improving the IUGR and reproductive performance,enhancing the antioxidant capacity and the possible mechanisms of their common substrate——NO.This review is respected to provide theoretical support for the application of Arg and h-Arg on pregnant sows.

Key words: arginine (Arg); homoarginine (hArg); NO; pregnant sow

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